PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G54680.1
Common NamebHLH105, EN133, ILR3, K5F14.2
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family bHLH
Protein Properties Length: 234aa    MW: 25487.9 Da    PI: 8.8356
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G54680.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH36.87.2e-1275122454
                  HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
          HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                  ++  rE++RRdr+N++f eL  +l +    + +K +Ka+iL  Av+ + +L
  AT5G54680.1  75 SKACREKQRRDRLNDKFMELGAILEPG---NPPKTDKAAILVDAVRMVTQL 122
                  5678**********************8...78**************99988 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF474599.95E-1462137IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000834.02E-1069127No hitNo description
PROSITE profilePS5088813.49771122IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.101.7E-1374144IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.6E-975122IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.3E-977128IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd146860.00513137169No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0046983Molecular Functionprotein dimerization activity
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000084anatomyplant sperm cell
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025195anatomypollen tube cell
PO:0025281anatomypollen
PO:0001016developmental stageL mature pollen stage
PO:0001017developmental stageM germinated pollen stage
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 234 aa     Download sequence    Send to blast
MVSPENANWI CDLIDADYGS FTIQGPGFSW PVQQPIGVSS NSSAGVDGSA GNSEASKEPG  60
SKKRGRCESS SATSSKACRE KQRRDRLNDK FMELGAILEP GNPPKTDKAA ILVDAVRMVT  120
QLRGEAQKLK DSNSSLQDKI KELKTEKNEL RDEKQRLKTE KEKLEQQLKA MNAPQPSFFP  180
APPMMPTAFA SAQGQAPGNK MVPIISYPGV AMWQFMPPAS VDTSQDHVLR PPVA
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.96390.0bud| flower| leaf| root| seed| silique
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO1453592450.0
Genevisible248171_at0.0
Expression AtlasAT5G54680-
AtGenExpressAT5G54680-
ATTED-IIAT5G54680-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Widely expressed throughout development, mostly in vasculatures. {ECO:0000269|PubMed:17028341}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor. Plays a role in resistance to amide-linked indole-3-acetic acid (IAA) conjugates such as IAA-Leu and IAA-Phe. May regulate gene expression in response to metal homeostasis changes. {ECO:0000269|PubMed:17028341}.
Function -- GeneRIF ? help Back to Top
  1. bHLH104 and ILR3 play pivotal roles in the regulation of Fe deficiency responses.
    [PMID: 25794933]
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT5G54680.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Interaction ? help Back to Top
Source Intact With
IntActSearch Q9FH37
Phenotype -- Disruption Phenotype ? help Back to Top
Source Description
UniProtDISRUPTION PHENOTYPE: Plants are more sensitive to IAA conjugates. {ECO:0000269|PubMed:17028341}.
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G54680
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF4886290.0AF488629.1 Arabidopsis thaliana clone bHLH105 putative bHLH transcription factor mRNA, complete cds.
GenBankAY0545850.0AY054585.1 Arabidopsis thaliana Unknown protein (At5g54680; K5F14.2) mRNA, complete cds.
GenBankBT0021890.0BT002189.1 Arabidopsis thaliana Unknown protein (At5g54680) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_200279.11e-173transcription factor ILR3
RefseqXP_002864351.11e-173hypothetical protein ARALYDRAFT_495549
SwissprotQ9FH371e-175ILR3_ARATH; Transcription factor ILR3
TrEMBLD7MUC31e-173D7MUC3_ARALL; Putative uncharacterized protein
STRINGAT5G54680.11e-173(Arabidopsis thaliana)
STRINGfgenesh2_kg.8__1365__AT5G54680.11e-173(Arabidopsis lyrata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM14372890
Representative plantOGRP7551766
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Heim MA, et al.
    The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.
    Mol. Biol. Evol., 2003. 20(5): p. 735-47
    [PMID:12679534]
  3. Toledo-Ortiz G,Huq E,Quail PH
    The Arabidopsis basic/helix-loop-helix transcription factor family.
    Plant Cell, 2003. 15(8): p. 1749-70
    [PMID:12897250]
  4. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  5. Bailey PC, et al.
    Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana.
    Plant Cell, 2003. 15(11): p. 2497-502
    [PMID:14600211]
  6. Rampey RA, et al.
    An Arabidopsis basic helix-loop-helix leucine zipper protein modulates metal homeostasis and auxin conjugate responsiveness.
    Genetics, 2006. 174(4): p. 1841-57
    [PMID:17028341]
  7. Wang Y, et al.
    Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.
    Plant Physiol., 2008. 148(3): p. 1201-11
    [PMID:18775970]
  8. Jaspers P, et al.
    Unequally redundant RCD1 and SRO1 mediate stress and developmental responses and interact with transcription factors.
    Plant J., 2009. 60(2): p. 268-79
    [PMID:19548978]
  9. Long TA, et al.
    The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots.
    Plant Cell, 2010. 22(7): p. 2219-36
    [PMID:20675571]
  10. Meinke DW
    A survey of dominant mutations in Arabidopsis thaliana.
    Trends Plant Sci., 2013. 18(2): p. 84-91
    [PMID:22995285]
  11. Selote D,Samira R,Matthiadis A,Gillikin JW,Long TA
    Iron-binding E3 ligase mediates iron response in plants by targeting basic helix-loop-helix transcription factors.
    Plant Physiol., 2015. 167(1): p. 273-86
    [PMID:25452667]
  12. Zhang J, et al.
    The bHLH transcription factor bHLH104 interacts with IAA-LEUCINE RESISTANT3 and modulates iron homeostasis in Arabidopsis.
    Plant Cell, 2015. 27(3): p. 787-805
    [PMID:25794933]